Abstract
We have previously demonstrated excellent agreement in the dog between thermodilution (TD) and lithium chloride dilution (LCD) as measures of CO, with an intraclass correlation of 0.989. LCD results in an accumulation of lithium (Li) in the body, which results in background interference for subsequent determinations. The manufacturer of the LCD sensor has calculated a theoretical upper serum Li value of 0.2 mmol L−1, above which interference may become significant. The purpose of this study was: (1) to determine the relationship between the dose of lithium chloride (LiCl) administered and the background serum Li level; and (2) to examine the relationship between background serum Li levels and the degree of agreement for CO measured by LCD and TD.
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