Abstract
THERE are several well-described, although not necessarily distinct, febrile, noninfectious, recurrent illnesses with normal-intervening intervals as follows: intermittent hydrarthrosis, familial Mediterranean fever (FMF), cyclic neutropenia (cyclic hematopoiesis), and periodic hypothalamic discharge. Although many of these disorders have been recognized for years, they are often misdiagnosed and frequently are discovered only after long and difficult diagnostic evaluation.1No specific origins characterize these disorders, and effective drug therapy is available for only two of these disorders: colchicine for FMF2and prednisone for cyclic neutropenia.3We report a case of recurrent fever and neutropenia that responded to therapy with lithium carbonate. The control of human body temperature is complicated and has recently been reviewed.4In patients with recurrent fevers, the following causes might be found: abnormal production or release of endogenous pyrogen from host phagocytic cells; abnormalities of the hypothalamic thermoregulatory center's response to endogenous pyrogen; or abnormalities of
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