Abstract
AbstractA concise improved method for the alkylation of the imidazole backbone has been developed. The positions 1 and 2 of the imidazole ring were protected with tetrahydro‐2H‐pyran‐2‐yl and chloro groups, respectively. Position 5 of imidazole was then lithiated, whereupon alkylation could be conducted by means of a variety of electrophilic reagents including haloalkanes, aldehydes, and ketones. Finally, the two protective / auxiliary groups on the positions 1 and 2 were easily removed by means of treatment with acid and base and hydrogenation, respectively. The developed method proved good functional group tolerance but demanded non‐bulky molecular moieties in the vicinity of the attaching C‐atom of the reagent. The novel alkylating method was used to synthesize two new NHC−Ag complexes holding branched alkyl groups on the imidazole backbone.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
