Literature Review for Management of Massive Hemorrhage

Abstract

Introduction: Management of massive hemorrhage has been advanced in the last decade and the survival rate of patients who suffered from massive hemorrhage had been improved. Evidence-based recommendations are required to guide the management of such situations, which when implemented may improve patient outcomes. Methods: Data were collected by review for articles, clinical trials and guidelines. Searches were restricted to articles written in English that were published during the period January 1988 through August 2015. The key recommendations in this article were made based on The Grading of Recommendations Assessment, Development and Evaluation (GRADE) system. Discussion: Over the recent years, massive hemorrhage is been managed by blood components transfusion and surgical or radiological intervention as applicable. With the advanced laboratory assays and point of care tests, surgical and radiological intervention methods and the availability of factor concentrates preparations, the survival of patients with massive hemorrhage has been improved significantly. Conclusion: This article discusses the available evidences and recommendations regarding management of patients with massive hemorrhage.