Literature Review: Cardiovascular Disorders and Minerals

Abstract

Tawfeeq et al. (2008) determined the altered status of some essential trace elements and antioxidant minerals in diabetic patients, which could have deleterious influences on the health of diabetics. The mean fasting plasma glucose (FPG) of type I and type II diabetics and BMI of type II diabetics showed statistically significant difference from control group. Mean serum copper of type I and type II diabetics showed statistically significant difference from control group. Simple linear correlation and regression analysis of the FPG level showed strong positive correlation to the Cu and Cu/Zn values in all study groups and negative correlation to the Zn values in all study groups. Also, HbA1c showed strong positive correlation to the Cu and Cu/Zn values among type I diabetics and control groups and negative correlation to the Zn values among type I diabetics and control groups. BMI and duration of diabetes showed no correlation with the Cu, Zn, and Cu/Zn values among all the study groups. They concluded that serum copper and Cu/Zn ratio increase significantly more than healthy control subjects, while serum zinc showed nonsignificantly reduced levels than healthy control participants, both in type I and II diabetes. Simple linear correlation and regression model analysis showed strong positive correlation of serum copper and Cu/Zn ratio as well as strong negative correlation of zinc toward the FPG values in all studied groups and furthermore toward HbA1c in type I diabetes and control group.