Abstract
Imidazole (IMID), (9.37 – 75 mg/Kg) and yohimbine (YOH), (0.5 – 2.5 mg/Kg), strongly potentiated lisuride-induced mounting, scored as a percentage of animals affected and mean number of mounts per animal, while clonidine (150 μg/Kg) significantly antagonized the phenomenon. A high (2 mg/Kg) but not a low (50 μg/Kg) dose of B-HT 920 and DPI (100 and 500 μg/Kg) also inhibited lisuride-induce mounting. While, at present, IMID specific activity on monaminergic system is not yet conclusive, it is demonstrated that, at the doses used, YOH and clonidine are selective α2 antagonist and agonist, respectively; B-HT 920 preferentially stimulates D2 receptors at 50 μg/Kg and α2 receptors at 2mg/Kg; finally DPI, proposed as DAi agonist, also activates α2 receptors. Therefore, in view of the dose-related receptorial selectivity of action of the drugs tested, neurochemical mechanisms on specific receptors involved for modulation of this form of sexual behaviour are briefly discussed.
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