Abstract
Listeria monocytogenes is an uncommon cause of illness in the general population. Meningoencephalitis is the most common central nervous system (CNS) manifestation of listeriosis. However, brain abscess represents 1-10% of all CNS listeriosis. To our knowledge, L. monocytogenes brain abscess in multiple myeloma patients has not been previously reported. Thus we report a 58-year-old male patient with multiple myeloma who developed a brain abscess due to L. monocytogenes. Due to a history of penicillin allergy, he was treated with intravenous trimethoprim/sulfamoxazole (TMP-SMX) for a total of 12 weeks, and gentamicin for the first two weeks, followed by oral therapy of TMP-SMX for a total of nine months. He is alive six and a half years after the diagnosis of myeloma with occasional brief seizures despite being on two anticonvulsants.
Highlights
Listeria monocytogenes is an uncommon cause of illness in the general population
Al-Khatti and Al-Tawfiq - Listeria monocytogenes infection and myeloma allergy, he was treated with intravenous trimethoprim/sulfamoxazole (TMP-SMX) (5 mg/kg of trimethoprim every six hours) for a total of 12 weeks and gentamicin for the first two weeks followed by oral therapy
L. monocytogenes brain abscess is an uncommon manifestation of listeriosis and accounts for 1-10% of all central nervous system (CNS) listeriosis
Summary
Frank brain abscess is an uncommon complication. L. monocytogenes may cause a small number of brain abscesses, representing 1-10% In a case series report, three of five patients with listerial brain abscess were cardiac transplant recipients [3]. There are only 40 cases of listerial brain abscesses described in the literature between 1968 and 2003 [4].
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