Liquisolid System and Liqui-Mass System Are Not the Same

Matthew Lam,Ali Nokhodchi,Taravat Ghafourian

doi:10.1208/s12249-020-01650-y

Abstract

This commentary is written in response to Pezzini’s research group commentary, which claimed Liqui-Pellet and liquisolid pellet are not different. Despite some similarities, there are crucial differences separating these two technologies. Liqui-Pellet uses liqui-mass system (wet mass/paste admixture), and liquisolid pellet uses liquisolid system (flowable powder admixture). The understanding of the well-defined term ‘liquisolid system’ is crucial to understand what is and is not liquisolid formulation. Spireas, who is the inventor of liquisolid technology, clearly defined liquisolid system in his patent document and publications. Since his first publication in 1998, there are around 200 articles about liquisolid formulations (extracted from Scopus), and with no exception, every single one of them followed the original definition of liquisolid system. Liqui-Pellet does not use liquisolid system and so calling it the same as liquisolid pellet, which uses liquisolid system, is incorrect and misleading. The purpose of this commentary is to resolve misunderstanding and support furthering knowledge.

Highlights

This commentary is written in response to Pezzini’s research group commentary, which claimed Liqui-Pellet and liquisolid pellet are not different
It has been shown that, liquisolid technology is capable of enhancing or controlling the drug release rate, it seems the industrial application of this technique may be hampered due to a few hurdles such as low load factor, poor flowability and poor compactibility
In order to have a high load factor, a wet mass system should be produced which is different from liquisolid system

Summary

Introduction

This commentary is written in response to Pezzini’s research group commentary, which claimed Liqui-Pellet and liquisolid pellet are not different. In order to have a high load factor, a wet mass system (non-flowable powder) should be produced which is different from liquisolid system (flowable powder). In the commentary written by Pezzini et al, it is mentioned that ‘liquisolid pellets (or liqui-pellets) are liquisolid system in nature’ and that the only difference is in the

Results

Conclusion