Abstract
The current article aims with the introduction of newer solubility enhancing technique as Liquisolid-pellet. The majority of newly invented molecules comes under the biopharmaceutical classification system (BCS) Class II, IV indicating poor solubility and thereby poor bioavailability. Liquisolid Compaq is one of the solubility enhancement techniques used for improving solubility and dissolution of the molecule by incorporating non-volatile solvent followed by carrier and coating agents. However, this technique is only applicable to potent molecules as a higher dose resulted in inconvenience to the patient and difficult to swallow. Another drawback of this method is not suitable for pilot plant scale-up. Liquisolid pellet technique overcoming all limitations of Liquisolid Compaq and offers good compaction, flowability, dose accuracy, less gastric irritations, and better bioavailability. In the Liquisolid-Pellet technique, powdered material received from Liquisolid Compaq is further moistened with granulating fluid to provide enough plasticity. The material is subjected to extrusion using an extruder to generate extrudates. The extrudates are placed under the spheronizer to form spherical particles as Pellets. The pellets are mainly prepared by extrusion-spheronization and hence, articles elaborate details of extruders and spheronizers, their specifications as well as factors, which strongly impart processing. These pellets are filled in capsules according to their dose and utilized as an immediate release or sustained release. The literature related to this review was collected from Science Direct, PubMed, Google Scholar, Google, USPTO, etc. from 1998 to 2020 with the following key-words.
Highlights
Most preference allotted to solid orals owing to their convenience, compliance, uniformity, and stability [1]
Liqui-pellet technique overcomes the limitations of Liquisolid Compaq, where a higher dose can be suitable for improving the solubility and final weight is quite low [32]
Liquisolid Compaq is such a technique utilized for the enhancement of poorly soluble active ingredient by incorporating non-volatile solvent
Summary
Most preference allotted to solid orals owing to their convenience, compliance, uniformity, and stability [1]. The Liquisolid concept was first demonstrated by Spireas and his team described that the active ingredients mostly exist as powder and hydrophobic Their solubility was improved by incorporating a liquid that is non-volatile to make it available as a solution or suspension [26,27]. Liqui-pellet technique overcomes the limitations of Liquisolid Compaq, where a higher dose can be suitable for improving the solubility and final weight is quite low [32]. Matthew Lam and his coworkers provided further clarification in 2020, that the Liquisolid-pellet were different from the Liqui-pellets Spireas in his patent, described that the Liquisolid powders should be flowable by adding more carriers, which in turn reduces load factor and makes the final dosage form, which was very bulky. Polyethylene glycol 200/400/600, propylene glycol, Polysorbate 20/80, Span, Labrafil, Labrasol and Kolliphor EL, etc. [37,38,39,40]
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