Abstract
The challenge faced by the majority of the pharmaceutical products is the poor solubility of the drug candidates which leads to low bioavailability. Liquisolid compact is one of the emerging techniques that enhances the dissolution of poorly water soluble drugs. Liquisolid system mentions to the formulation made by the transforming the liquid drug, either in the form of suspension or solution in non volatile solvents into a dry, non-sticky, free-flowing and compactable powder mixtures. This is achieved by mixing the suspension or solution of the drug with appropriate carriers and coating agents. The technology has the ability to increase aqueous solubility, rate of dissolution and absorption of poorly soluble drug by keeping it in molecularly dispersed form leading to its improved bioavailability when compared to conventional tablets. Liquisolid technology is the impending approach for enhancing the solubility of poorly water-soluble drug by adopting simple manufacturing process and low production cost.
Highlights
Drugs belonging to biopharmaceutics classification system (BCS) class II encounter the problem of low solubility, dissolution rate which leads to poor bioavailability [1]
The drug can be formulated as a tablet or a capsule or as an encapsulated liquisolid microsystem, where the drug is presented in solubilized state which leads to enhanced wetting phenomena and improvement in drug release profiles
The incorporation of high dose water-insoluble drugs can be achieved by additives polyvinyl pyrrolidine (PVP), hydroxyl propyl methyl cellulose (HPMC), polyethene glycol (PEG) 35000 [15]
Summary
Drugs belonging to biopharmaceutics classification system (BCS) class II encounter the problem of low solubility, dissolution rate which leads to poor bioavailability [1]. “Liquisolid technology” referred to as “powder solution technology” In this technology, a formulation is prepared by converting liquid drugs i. E solution or suspension from of drug in nonvolatile solvents into a dry non-sticky, compressible, smoothly flowing powder This is achieved by mixing the drug suspension or solution with designated carriers and coating agents [3]. The drug can be formulated as a tablet or a capsule or as an encapsulated liquisolid microsystem, where the drug is presented in solubilized state which leads to enhanced wetting phenomena and improvement in drug release profiles. Drug release can be improved by using suitable formulation excipients such as hydrophobic carriers (Eudragit RL) for sustained release, use of surface active agents (polysorbate 80) for improved wettability and enhanced dissolution profile can be accomplished. The manufacturing efficiency can be improved [7,8,9]
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