Liqui-pellets as a Novel Approach in the Formulation of Oral Solid Products

Abstract

In dosage form design, rather particular interest is shown towards solid oral products as they are versatile and highly preferred by the pharmaceutical manufacturing industry. To tackle poor dissolution and bioavailability of problematic drugs, liquisolid technology is developed, from which further advances like liqui-pellet's originated. The latter requires lower economic investment than the liquisolid formulation technology. Some limitations in the liquisolid technology are inadequate flowability, compressibility and the inability to manufacture high-dose oral products, which are very difficult to administer. Overall, the liqui-pellets would overcome the inadequate flowability of the liquisolid formulation adding a better drug release ability. These problems can be resolved by employing the liqui-pellets. This review article provides information about liqui-pellets' advantages, the preparation method, factors affecting them and evaluation studies. The main background areas like liquisolid technology, extrusion and spheronization technology are also discussed. The liqui-pellet system is a significant innovation in oral solid drug products.