Abstract
Abstract In order to investigate the influence of the content and the chain length of a peptide anchored to a soluble polymer support on the reactivity of the amino-free terminal of the peptide, chloromethylated polystyrene, which is a starting material for peptide synthesis on a matrix, was prepared by the copolymerization of (chloromethyl)styrene with styrene. By the copolymerization, the chloromethyl content on the resin was easily controlled and obtained as reproducible. The repetitive peptide-chain elongations of a pentapeptide, –(Ala2–Leu3)–, and a decapeptide, –(Ala2–Leu3–Pro2–Leu3)–, were performed by the usual method, using soluble polymer supports with various contents of Ile–Ile, which was used as the internal reference to evaluate the coupling yields by means of amino-acid analyses of the resulting peptide resins. The solubility of the peptide resin, which depends on the content of the peptide and the solubility of the peptide fragment on the matrix, was found to be one of the important factors for an efficient coupling in liquid-phase fragment condensations on a soluble polymer support.
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