Liquid-like protein interactions in fast endophilin mediated endocytosis

Abstract

Cells use a variety of endocytic pathways to mediate their interaction with the environment. Clathrin-mediated endocytosis is the most studied pathway of endocytosis; however, there are also several clathrin-independent endocytic pathways that the cell uses to meet specific needs. Fast endophilin-mediated endocytosis (FEME) is one such clathrin-independent pathway, which is utilized by the cell for fast, controlled uptake. Specifically, FEME only proceeds after activation of specific receptors. To achieve triggered uptake, the FEME pathway utilizes an active priming mechanism that clusters Endophilin at the membrane surface, where it is recruited by Lamellipodin.