Abstract
liquid formulations of ester- and amide-based local anesthetics are developed by forming Deep Eutectics considering monoterpenoids. Acyclic, monocyclic, and bicyclic monoterpenoids were considered leading to stable formulations for all the considered local anesthetics. The developed formulations were characterized by their relevant physicochemical properties. Their permeabilities using model lipid bilayers were also studied, and the hydrophobicity in terms of octanol–water partition coefficients. Likewise, molecular docking studies on a selected target protein were carried out to analyze the behavior of the developed formulations in comparison with neat local anesthetics.
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