Abstract
The effect of adding aliphatic linear chain carboxylic acids to mobile phases used in separation of solutes of widely varying functionality on microparticulate silica was investigated. Changes in peak shape and retention time of varied solutes as a function of mobile phase acid chain length are described. Peak shape generally improves with increasing acid chain length, especially for acidic solutes. Retention of acidic solutes decreases with decreasing acid chain length; basic solutes exhibit the opposite behavior. These and other effects are discussed in conjunction with a propsed retention mechanism. Potential for application of this type of chromatographic system for rapid assessment of chemical types in complex samples is discussed.
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