Abstract
A time-of-flight desorption mass spectrometer utilizing 252Cf fission fragment induced ionization analyses samples of nonvolatile organic solids nondestructively. Using a 7 μCi 252Cf-source and thin samples (0.1 - 10 μg cm −2) a complete mass spectrum (m/z 1 −1000) is obtained in approximately 1 minute. The spectrometer is combined with a high-performance liquid chromatograph via an interfacing disk samplin up to 12 fractions of involatile compounds in the effluent (⋍ 0.5 cm 3 min −1 MeOH-H 2O) under rough vacuum conditions (⋍ 1 mbar) in a vacuum-drying process. This combined LC/MS method has been applied for the quantitative analysis of antitumor drugs in human serum.
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