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Abstract
A simple liquid chromatography-electrospray ionization mass spectrometry (LC-ESI-MS) method has been developed and validated for the simultaneous determination of Atorvastatin (ATO) and telmisartan (TEL) in human plasma. After liquid-liquid extraction step, the analytes and internal standard, rosuvastatin (ROS) were separated using an isocratic mobile phase consisting of 10 mM ammonium acetate (pH=4)-methanol (20:80, v/v) on a reverse-phase C18 column. Detection was carried out on mass spectrometer by using electrospray ionization (ESI) source using their respective [M+H] + ions, m/z 482 for ROS, m/z 515 for TEL, and m/z 559 for ATO. For both drugs, the method was linear in the range of 1-35 ng/mL. Acceptable precision and accuracy were obtained for concentrations in the calibration range.
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