Abstract

Atmospheric pressure ionization (API) mass spectrometry is a novel form of mass spectrometry in which ions are generated in a reaction chamber external to the low-pressure region of a quadrupole mass spectrometer. Using this ionization technique a liquid chromatograph—mass spectrometer analytical system was constructed. The entire effluent stream from the chromatograph is vaporized throught the API source. The primary ionization source for this work was a corona discharge The very high ion densities generated by the corona discharge extend the linear range of the API source into the microgram region.

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