Abstract
Reversed-phase liquid chromatographic (RP/LC) procedures are used to optimize the reaction conditions for the large scale preparation of 2,2-dimethyl-N-benzylmalonamide, 1. In acute studies using mice and rats, compound 1 is a very effective anticonvulsant agent. Large quantities of 1 (ca. 300 g) are needed for detailed studies of its chronic effects. LC monitoring of the synthesis of intermediate products and 1 result in the optimum use of reagents, increased product yields, and decreased reaction times.
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