Abstract
A reversed-phase LC method using UV detection has been developed and validated for the analysis of methylparaben and propylparaben in nortriptyline hydrochloride oil-water (o-w) microemulsions. The precision and accuracy of the method was excellent with RSD values of 4.53% and 2.13% respectively for methylparaben, and 3.69% and 2.06% respectively for propylparaben. The linearity established was 50–150% of theoretical concentrations of each product in dosage form, withr 2 0.9940 for methylparaben and 0.9956 for propylparaben. Recoveries of all products from spiked placebos were >95%, with detection limits 0.86 µg · mL−1 for methylparaben, and 0.06 µg · mL−1 for propylparaben. The method was successfully used for determining both compounds in nortriptyline o-w microemulsions.
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