Abstract

Abstract A reversed-phase (C18) liquid chromatographic (LC) method was developed for the analysis of 5 sulfonamides (sulfadiazine [SDZ], sulfamerazine [SMRZ], sulfamethazine [SMTZ], sulfadimethoxine [SDMX], and sulfapyridine [SP]) in salmon muscle tissue. Spiked tissue samples were extracted by matrix solid-phase dispersion. The LC mobile phase gradient consisted of acetonitrile-aqueous 0.01M ammonium acetate (pH 5.5). The potentiators trimethoprim and ormetoprim were also resolved with this chromatographic system. The method detection limits at the 99% confidence level were 48,66,228, and 150 ppb for SP, SMRZ, SMTZ, and SDMX, respectively, and approximately 100 ppb for SDZ. The average percent recoveries of analytes from salmon muscle tissue were 66,66,71,82, and 75% for SDZ, SP, SMRZ, SMTZ, and SDMX, respectively

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