Abstract
Liquid Biopsy in Oncology: Myth or Reality?
Highlights
One of the most relevant challenge in oncology would be the ability to deeply know tumoral genetic aspects through technological innovation and translational research to be able to personalize oncological treatment based on classical patient’s clinical characteristics and on its tumoral genetic portrait
Represent the molecular heterogeneity of the disease compared to the tissue biopsy, potentially containing tumor DNA deriving from the different areas of the same tumor, in the presence of tumor heterogeneity, it provides little information on the representativeness in the context of the tumor of the biomarker identified
Other potential limitations of liquid biopsy could be related to false negative (Insufficient DNA shed into plasma, insufficient sensitivity in older assays) or false positive conditions
Summary
One of the most relevant challenge in oncology would be the ability to deeply know tumoral genetic aspects through technological innovation and translational research to be able to personalize oncological treatment based on classical patient’s clinical characteristics and on its tumoral genetic portrait. Liquid biopsy in oncology: myth or reality?
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