Liquid-Based Cytology Sensitivity for Detection of Adenocarcinoma of the Cervix

Abstract

period ending December 31, 2011. The time interval between screening episodes was also recorded. The data was analyzed using Microsoft Excel software. Results: Of the 3394 co-tests ordered for 3394 patients with negative initial Pap results, 3173 (93.4%) were HR-HPV negative, 173 (5.0%) were HRHPV positive and 65 (1.9%) showed equivocal HPV testing (Table 1). Among the 3173 women who had initial dual-negative results; 2228 patients had 3938 repeat Pap tests performed during the study period, with 2101 of them being repeat co-tests. The number of repeat Pap tests and repeat co-tests are displayed in Table 2. Nine hundred thirty nine (939) repeat co-tests were performed within two years of an initial negative co-test, accounting for 44.7% of the repeat co-tests within the study period. The repeat Pap tests for all patients with an initial dual-negative co-test resulted in the following cytologic diagnoses: 3331 no squamous intraepithelial lesion or malignancy (negative), 127 Atypical squamous cells of undetermined significance (ASCUS), 45 Low-grade squamous intraepithelial lesions and 9 High-grade squamous intraepithelial lesions. The dualnegative patients received a total of 621 follow-up gynecologic biopsies.