Abstract
The trichloroacetimidate group is one of the most versatile leaving groups in organic synthesis. This is evident by its involvement in quite a number of total syntheses. Typical methods of preparation generally involve the use of toxic and hazardous solvents, specifically dichloromethane and chloroform. Liquified Dimethyl ether (DME), was investigated as an alternative solvent in the synthesis of commonly utilized trichloroacetimidates. A range of alcohol substrates were employed and moderate to excellent yields of the corresponding imidates were obtained. The low boiling point (−24 °C) of DME allows for rapid evaporation at atmospheric pressure, and its facile recovery.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
