Abstract
Two new sphingolipids, stewartins A: [(2S,3S,4R)-2-{[(2R,11E)-2-hydroxyoctadec-11-enoyl]amino}tetraeicosane-1,3,4-triol-1-O-β-D-glucopyranoside, 1] and B: [(2S,3S,4R)-2-{[(2R,11E)-2-hydroxyeicos-11-enoyl]amino}tetraeicosane-1,3,4-triol-1-O-β-glucopyranoside, 2], along with nine known compounds (3–11) were isolated from the n-hexane soluble fraction of the methanolic extract of the whole plant of Phlomis stewartii. Compounds 1, 2, 4, and 6 showed inhibitory potential against the enzyme lipoxygenase (LOX) in a concentration-dependent manner with IC50 values ranging between 42.2 ± 0.2 to 55.7 ± 0.8 μM, whereas compounds 3, 5, and 7–11 showed inhibition against enzyme the α-glucosidase with IC50 values between 201.4 ± 0.6 to 277.7 ± 0.3 μM, respectively.
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