Abstract
RATIONALE: Lipoxin A4 (LXA4) is an arachidonic acid-derived autacoid with distinct role in promoting resolution of acute inflammation. Low level of LXA4 is linked to excess of granulocyte rich airway inflammation and is observed in the course of severe asthma. GM-CSF is considered as one of key regulators of inflammatory processes in the lung and allergic reaction. The effect of LXA4 on GM-CSF-mediated pathologies has not been investigated. Using phosphoproteomic techniques, we aimed to study the effect of LXA4 on GM-CSF-induced signaling pathways and cell activation.
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