Abstract
Beta-Lipotropic Hormone (LPH) was estimated in pituitary and brain by a radioimmunoassay specific for the N-terminal, non-opiate portion of the protein, and endorphin activity by an opiate radioreceptor assay. The intermediate pituitary is most concentrated in LPH and endorphin. Gel filtration indicated the presence in the pituitary of intact LPH and N-terminal fragments but only intact LPH in brain. Endorphin activity in pituitary is associated primarily with a component of 3000 daltons and to a lesser extent with one of about 2000 daltons. Brain endorphin activity is mostly accounted for by a 2000 dalton component, enkephalins representing an apparently minor activity. In pituitary and brain LPH and endorphin are entirely associated with a 12,000 g/10 min fraction.
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