Abstract
Encapsulation of carboquone (CQ) in liposomes was investigated by applying a reverse-phase evaporation vesicle (REV) method, and the in vitro release of CQ from the liposomes was also studied. The mean diameter of the liposomes was 0.2μm. The encapsulation efficiency in liposomes was greatly affected by the materials used for the membrane of the liposomes. The efficiency increased with a rise in the phase transition temperature of the phospholipids, the maximum encapsulation of CQ in liposomes being obtained with distearoyl phosphatidylcholine. The results of drug release showed that CQ remained in CQ-liposomes for a long time at 5°C but was released considerably faster at around the phase transition temperature (58°C) of distearoyl phosphatidylcholine.
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