Abstract
目的 探讨氟尿嘧啶脂质体兔眼玻璃体内注射对增生性玻璃体视网膜病变的防治作用.方法 10只白色家兔,每只眼玻璃体内注射自体腹腔收集巨噬细胞制成增生性玻璃体视网膜病变动物模型.右眼为实验眼,玻璃体内注射氟尿嘧啶脂质体1次,浓度为1.6mg/0.1mL;左眼为空白对照,注射磷酸缓冲液.每周观察玻璃体视网膜病变发展程度.4周观察术后视网膜脱离发生率.结果 术后28天,实验组视网膜脱离发生率为30.00%(3/10),对照组为80.00%(8/10),差异有统计学意义.结论 玻璃体内注射氟尿嘧啶脂质体1次能有效地预防实验性增生性玻璃体视网膜病变的发生。
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