Abstract
The addition of a large excess of heptakis(2,6-di-O-methyl)-β-cyclodextrin (DMe-β-CDx) led to the collapse of several liposomes via the formation of water-soluble lipid–DMe-β-CDx complex with allosteric interactions.
Highlights
Cyclodextrins (CDxs) and their derivatives are water-soluble host molecules with a hydrophobic cavity.[1]
The aqueous solubility of b-CDx was too low to measure the intensity of its light scattering at 450 nm by UVvis absorption spectroscopy under the same conditions ([bCDx]/[DLPC] 1⁄4 0–5 equiv.) (Fig. 1A)
Similar phenomena have been observed following the addition of a suitable lysing agent or a surfactant under aqueous conditions, the lipid–DMe-b-CDx complexes generated in the current study were applicable to the Hill plots because the peaks of the lipids in the lipid–DMe-b-CDx complexes could be detected by 1H NMR spectroscopy
Summary
Cyclodextrins (CDxs) and their derivatives are water-soluble host molecules with a hydrophobic cavity.[1]. The light scattering intensity (A/A0 at 450 nm) of a 1,2-dimyristoyl-snglycero-3-phosphocholine (DMPC)-based liposome decreased following the addition of DMe-b-CDx (Fig. 1A).
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