Abstract
Effectiveness of a new photosensitizer (PS) liposomal amidoaminchlorine for PDT was studied on a tumor model of rat sarcoma М-1. The research objective: to define parameters of PS minimum effective dose and laser irradiation to achieve complete regression of the tumor. Dynamics of PS accumulation in tumor and healthy tissue was studied to define the PDT time course and antitumor efficiency of different PS doses and various parameters of laser irradiation. The study results defined the optimum term for PDT and minimally effective PS dose and established the parameters for laser irradiation.
Highlights
Фотодинамическая терапия – направление противоопухолевой терапии, в котором воздействие на ткань опухоли введенного фотосенсибилизатора инициируется световым излучением, поглощаемым этим фотосенсибилизатором [5; 7; 8; 14; 15; 19; 21]
liposomal amidoaminchlorine for PDT was studied on a tumor model of rat sarcoma М-1
The study results defined the optimum term for PDT
Summary
ФОТОСЕНСИБИЛИЗАТОР ЛИПОСОМАЛЬНЫЙ... М.А. Каплан[1], А.И. Малыгина[1], Г.В. Пономарев[2], А.А. Михайловская[1], В.В. Дрожжина[1], Л.М. Архипова[1], Ю.С. Осипчук[1]
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