Abstract
As scientists in the field of drug delivery, the endeavor to constantly improve strategies for the specific delivery of the drug to its target cannot be over exaggerated! This field has been evolving constantly and has now come a long way from the classic small molecules to targeted drug delivery systems and now, one of the most recent transformations, “Focal drug delivery” (FDD). From recent literature that will be described in the course of this chapter, it could be derived that FDD is a drug delivery scheme to “encapsulate the drug to form a non-leaky/inert package and then zap it with ultrasound (US) at the desired site for therapeutic action.” This chapter will mainly focus on liposomes as the drug-packing agents for FDD, mainly dealing with cancer therapy, but will also include several other recent non-cancer-related therapies that employ liposomal focal drug delivery (LFDD). Also, from available literature, focused ultrasound, i.e., ultrasound (US) that can be narrowed to a small foci of interest, seems to be the rational choice for zapping the liposomal carrier to preclude off-target effects. However, there are several studies that have successfully shown FDD using clinical grade US. All such studies related to application of LFDD in cancer therapy will be covered first in this manuscript followed by the application of LFDD to non-cancer therapies.
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