Abstract

High values of lipoprotein(a), related to atherosclerosis progression, are often considered a marker of thrombosis. Weassessed the lipoprotein(a) profile in a group of patients with high vascular risk and no cardiovascular events, established its correlationwith other cardiovascular risk factors and inferred the results for patients with metabolic disorders and, at least, two risk factors. This longitudinal observational study included 516 patients, who had at least two cardiovascular risk factors andregularly attended, for at least two years, the outpatient consultations at a clinic of metabolism and vascular risk for primary prevention.Sociodemographic, clinical and anthropometric parameters were obtained at the baseline visit. Hepatic morphology was assessedin 509 patients (98.6%) by ultrasonography. The 10-year vascular risk was estimated using Framingham risk score, atheroscleroticcardiovascular disease and systematic coronary risk evaluation tables. Significant correlations were found between lipoprotein(a) levels and the addressed vascular risk factors, as well as between lipoprotein(a), and Framingham risk score, atherosclerotic cardiovascular disease and systematic coronary risk evaluation charts.Lipoprotein(a) values were also considerably higher in patients with steatosis. Increased lipoprotein(a) values were directly associated with all markers of cardiovascular risk and with non-alcoholichepatic steatosis. Due to its high availability and low cost, lipoprotein(a) should become part of the routine evaluation of patients at vascularrisk.

Full Text
Published version (Free)

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call