Lipoprotein Profile in Populations from Regions of the Russian Federation: ESSE-RF Study.

Victoria A Metelskaya,Eugeny V Shlyakhto,Svetlana A Shalnova,Vladimir A Kutsenko,Elena B Yarovaya,Sergey A Boytsov,Oxana M Drapkina

doi:10.3390/ijerph19020931

Victoria A Metelskaya, Eugeny V Shlyakhto + Show 5 more

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https://doi.org/10.3390/ijerph19020931

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Abstract

This study aimed to describe the dyslipidemia prevalence and pattern among adult populations from different regions (n = 13) of the Russian Federation (RF). Randomly selected samples (n = 22,258, aged 25–64) were studied according to the ESSE-RF protocol. Lipoprotein parameters were estimated by routine methods. Statistical analyses were performed using R software (v.3.5.1). The overall dyslipidemia prevalence was 76.1% (76.9/75.3% for men/women). In women, total cholesterol (TC) and low-density lipoprotein (LDL)-C levels gradually increased with age (from 4.72 to 5.93 and from 2.76 to 3.79 mmol/L, respectively); in men, they reached a maximum by 45–54 (5.55 and 3.55 mmol/L, respectively) and then decreased. No differences in high-density lipoprotein (HDL)-C in men of different ages were found, but slight decreases in HDL-C and apo AI were observed in women by 55–64 years. No pronounced associations between education and lipid levels in men were observed; higher-educated women showed significantly better lipoprotein profiles. Similar associations between lipids and income level were detected. Women from rural areas had higher TC and triglycerides than urban residents. Regardless of sex, rural residents had higher HDL-C and apo AI, and reduced apo B/apo AI. Conclusion: Information on the peculiarities of dyslipidemia prevalence and lipoprotein profile depending on sex, age, residential place, and socioeconomic status is useful for assessing the global ASCVD risk, and for risk modeling based on national data.

Highlights

Atherosclerosis-related cardiovascular diseases (ASCVDs) are the leading cause of death: about 17.9 million people died from these diseases in 2019, representing 32% of all global deaths [1]
(Epidemiology of Cardiovascular Diseases and their Risk Factors in Some Regions of the Russian Federation) study is the first population study conducted in Russia during the last two decades, which is considered as a continuation of preventive activity, in order to obtain unbiased information about the epidemiological characteristics of the
This study aimed to describe the dyslipidemia prevalence and pattern among adult populations from different regions of the Russian Federation (RF), studied according to the ESSE-RF protocol

Summary

Introduction

Atherosclerosis-related cardiovascular diseases (ASCVDs) are the leading cause of death: about 17.9 million people died from these diseases in 2019, representing 32% of all global deaths [1]. Clinical, and experimental studies, dyslipidemia (serum lipid transport abnormalities) is regarded as one of the most powerful modifiable ASCVD risk factors, and people having this disorder are at increased risk of developing these diseases as compared to normolipidemics [2]. Epidemiological studies are an important scientific tool for assessing the prevalence of ASCVDs and their risk factors, as well as predicting their outcomes. The ESSE-RF (Epidemiology of Cardiovascular Diseases and their Risk Factors in Some Regions of the Russian Federation) study is the first population study conducted in Russia during the last two decades, which is considered as a continuation of preventive activity, in order to obtain unbiased information about the epidemiological characteristics of the.

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