Abstract
A situation of maximal triglyceride (TG) hydrolysis was generated in normals and patients with type III hyperlipoproteinemia by a large oral fat load and subsequent heparin administration one hour after the fat meal. Lipoprotein fractions [chylomicrons, very low density lipoproteins (VLDL), low density lipoproteins (LDL1 d 1.006-1.019, LDL2 d 1.019-1.063), and high density lipoproteins (HDL2 d 1.063-1.125, HDL, d 1.125-1.25)| were obtained by zonal or preparative ultracentrifugation and subsequent chromatography on 2% agarose. Electron microscopy was performed on full plasma and lipoprotein fractions by using the techniques of negative staining, freeze etching, shadowing and scanning electron microscopy (SEM). The lipoprotein morphology thus obtained was compared with that of type I hyperlipoproteinemia and of Zieve's syndrome. All conditions investigated had some abnormal lipoprotein structures in com mon: 1) Liposome-like particles (500-4000 A) in the intermediate molecular weight (IMW) fraction of d 1....
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