Lipoprotein lipase activity of human adipose tissue in health and in some diseases with hyperlipidemia as a common feature.

Abstract

Abstract Adipose tissue lipoprotein lipase activity (LPLA), serum triglycerides, cholesterol and free fatty acids (FFA), blood glucose and aceto‐acetate have been determined in groups of 50 healthy men and 50 healthy women. Groups of subjects with atherosclerotic disease, diabetes and impaired glucose tolerance, high alcohol consumption, uremia and some patients with myxedema, nephrosis and insuloma have been studied in the same way. In comparison with a majority of normo‐ and hyperlipidemic subjects the relation between LPLA and serum lipids did not seem to be modified by either atherosclerotic disease or different degrees of glucose intolerance. On the contrary, in subjects with alcohol overconsumption LPLA was normal or high, in spite of a high incidence of hyperlipidemia. Thirty uremic subjects were characterized by low LPLA, increased levels of serum triglycerides, cholesterol and blood aceto‐acetate, while serum FFA was low.