Lipoprotein (a) levels in newly diagnosed treatment naive type 2 diabetics & it’s correlation with glycemic & lipid parameters

Abstract

Type 2 diabetes mellitus (T2DM) has a high morbidity and mortality mainly due to cardiovascular diseases. Besides traditional risk factors, Lp(a) has recently been emerged as an independent risk factor. This study aimed to evaluate the incidences of elevated Lp(a) levels in newly diagnosed T2DM Pts and to find the pattern of lipid profile abnormalities associated with elevated Lp(a) group of pts & it’s correlation with glycemic & lipid parameters.This present study was conducted in newly diagnosed treatment naïve type 2 diabetic patients. After obtaining informed consent, all participants completed a survey to obtain anthropometric & clinical information. Venous blood samples were drawn for fasting plasma glucose, postprandial glucose, HbA1c,lipid profile & Lp(a) measurements.A total 70 newly diagnosed type 2 diabetic pts & 50 healthy controls were studied. The mean Lp(a)level measured among diabetics was 34.17 ±33.25 mg/dl. The mean concentration of Lp(a) in diabetics was significantly higher than control group(<0.001). Lp(a) was positively correlated with 2hr PP glucose, HbA1c and these correlations were statistically significant. The Lp(a) was negatively correlated with HDLc & this correlation was statistically significant(0.04).Our study demonstrated Type 2 diabetics had statistically significant higher levels of Lp(a). The residual lipid risk is probably contributed by this molecule So, every diabetic should have checked their level at least once in a lifetime to predict CV risk.