Abstract
This study was carried in BSMMU from July 2001 to June 2003. During the study period, 60 pregnant women were studied. Thirty patients were preeclamptic and thirty were normal healthy pregnant women served as control. Serum lipoprotein(a) was found significantly higher in preeclamptic women 56.63 +/- 22.6 mg/dl and found within limit in normal healthy pregnant women, 12.89 +/- 4.59 mg/dl. Result is statistically highly significant (P < 0.001). Mean systolic blood pressure was 163.33 +/- 29.63 mmHg and 117.00 +/- 11.19 mmHg in case and control and Diastolic Blood Pressure was 108.53 +/- 14.54 mmHg and 76.00 +/- 6.87 mmHg respectively in case and control group. Result was highly significant as P < 0.001. The mean (+/- SD) serum lipoprotein(a) concentration in normal pregnancies and preeclampsia were found to be 12.91 +/- 4.94 and 56.65 +/- 22.62. Moderate proteinuria was found in 77.5% and severe proteinuria in 22.2% cases of preeclampsia respectively. Regardless of mechanism and pathophysiology of preeclampsia, we found high serum level of lipoprotein (a) in preeclampsia patients. These high levels of lipoprotein (a) significantly correlated with blood pressure and proteinuria.
Highlights
Preeclampsia in hypertension associated with proteinuria ≥ 300mg in 24 hours urine or Igm/L in any random sample of urine and with or without oedema occurring primarily in nulliparous women after the 2nd half of gestation and most frequently near term
Serum from 30 normal and 30 preeclampsia patients were prepared at BSMMU and DMCH and kept under 40OC at BIRDEM until analyzed for serum Lp(a) level by special lipoprotein assay kit
The present study dealt with a significant number (n=30) of preeclampsia case where high serum lipoprotein (a) level, i.e. more than 30mgld, which has been set as a cut -Off level, associated with increased of thrombosis and atherosclerosis.[7]
Summary
Preeclampsia in hypertension associated with proteinuria ≥ 300mg in 24 hours urine or Igm/L in any random sample of urine and with or without oedema occurring primarily in nulliparous women after the 2nd half of gestation and most frequently near term. Preeclampsia occurs in about 5 to 15 percent of the general population[2]. Preeclampsia is a serious complication of the second half of pregnancy that occurs with a frequency of upto 15 percent[2]. Altered coaguability may be important in the pathogenesis of preeclampsia. This study has been designed to measure and analyze the concentrations of lipoprotein (a) level in maternal serum, to find out its significance in the pathogenesis of preeclampsia
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