Abstract
Lipoprotein(a), apolipoprotein(a) polymorphism and coronary artery disease severity in type 2 diabetic Tunisian population
Highlights
Lipoprotein (a) (Lp[a]) is composed of a low-density lipoprotein (LDL) particle and a glycoprotein molecule known as apolipoprotein(a) [apo(a)] [1]
Lp(a) levels and the percentages of patients with at least one isoform of low molecular weight (MW) were significantly correlated with the increasing extent of the coronary artery disease (CAD)
When apo(a) phenotypes were added to the list of potential predictors, the analysis showed that apo(a) polymorphism (OR: 3.33; 95% CI: 1.53–6.44; p =0.001), BMI
Summary
Lipoprotein (a) (Lp[a]) is composed of a low-density lipoprotein (LDL) particle and a glycoprotein molecule known as apolipoprotein(a) [apo(a)] [1]. Lp (a) is an independent risk factor not dependent on LDL. Few studies have analyzed the possible role of apo(a) polymorphism in relation to the severity of coronary atherosclerosis [5]. Several investigations show an independent association of Lipoprotein(a), homocysteine and apo( a) polymorphism with silent CAD [6,7,8,9]. Lipoprotein (a) [Lp(a)] is an important genetic risk factor for coronary artery disease (CAD), but there is not enough data in the literature about the association between Lp(a) levels and the severity of CAD in diabetic patients. The aim of theis study was to investigate the association of the severity of coronary atherosclerosis with Lp(a) levels and apo(a) polymorphism in a type 2 diabetic Tunisian population
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