Abstract
BackgroundRecently few studies tried to confirm the association between AF and lipoprotein(a) (Lp(a)), however the results remained conflicted. In present study we evaluated the possible interaction between Lp(a), inflammatory state and echocardiographic characteristics in patients after successful electrical cardioversion (EC) of persistent AF. We also tried to investigate the role of Lp(a) as a possible prognostic factor for AF recurrence after successful EC.ResultsData of 79 patients admitted due to planned EC was analyzed. After successful procedure patients were monitored for 2 years. For analytical purposes patients were divided in two groups according to AF recurrence. There was no significant difference between Lp(a) levels in both groups. We also didn't find any positive correlation between Lp(a) and CRP levels, as well as between Lp(a) levels and left atrium diameter. For logistic and survival analysis optimal cut-off value of Lp(a) ≥ 0.32 (upper quartile) was used. In logistic regression model with AF recurrence as dependent variable Lp(a) didn't show any statistically significant association with AF recurrence. Survival analysis showed slightly higher AF recurrence rate in group with higher Lp(a) levels but not to the level of statistical significance (log rank test, p = 0.62).ConclusionsWe weren't able to confirm the association between Lp(a) levels and AF recurrence, inflammation and left atrium diameter in patients after successful EC of persistent AF. Further studies are needed to elucidate the role of Lp(a) in this clinical setting.
Highlights
Atrial fibrillation (AF) is one of major causes for morbidity and hospitalization [1]
In past years few studies tried to elucidate the association between AF and lipoprotein(a), in connection with thrombembolic complications [8,9]
In this study we evaluated the possible interaction between Lp(a), cholesterol levels and inflammatory state in patients after successful electrical cardioversion (EC) of persistent AF
Summary
Atrial fibrillation (AF) is one of major causes for morbidity and hospitalization [1]. It is important risk factor for thrombembolic complications and cerebrovascular disease [2]. In past years few studies tried to elucidate the association between AF and lipoprotein(a), in connection with thrombembolic complications [8,9]. Major component of lipoprotein (a), or Lp(a) is large glycoprotein molecule named apoprotein(a), which is produced in hepatocytes. It binds with apo B100 component of LDL to form Lp(a). Few studies tried to confirm the association between AF and lipoprotein(a) (Lp(a)), the results remained conflicted. We tried to investigate the role of Lp(a) as a possible prognostic factor for AF recurrence after successful EC
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