Abstract
Eisenbarth SC, Piggott DA, Huleatt JW, et al. J Exp Med . 2002;196:1645–1651 To evaluate the dose-dependent effects of lipopolysaccharide (LPS) (endotoxin) inhalation and LPS-induced activation of toll-like receptor 4 (TLR4) on the generation of T helper (Th) cell type 2-dependent allergic inflammatory responses to an inhaled antigen, ovalbumin (OVA). Wild-type or TLR4-deficient, 6- to 10-week-old, female mice were studied. Mice were sensitized with intranasal exposure to LPS-depleted OVA or OVA with either a low (0.1 μg) or high (100 μg) dose of LPS. After intranasal OVA challenge, pulmonary inflammatory responses …
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