Abstract
The aim of the study was to test the hypothesis that control of breathing via Hering–Breuer reflex (HB) is influenced by lipopolysaccharide (LPS)-induced fever in rats. Animals were injected intraperitoneally with LPS and control group with an equivalent volume of saline. HB reflex was elicited by inflations of the lungs followed by occlusion of the airways under control of esophageal pressure. Duration of HB reflex (Tapnoe) was continuously reduced as body temperature rose during experiment. Compared to normothermic controls, animals with fever had significant shortening of Tapnoe at 240min and 300min after LPS administration. Fever was further accompanied by a reduction in the strength of HB reflex (inhibitory ratio, IR). In comparison with controls, significant decrease of IR was observed at 300min after LPS injection. Conclusion: altered neural control of breathing demonstrated by decreased power of Hering–Breuer inflation reflex in conditions of LPS-induced fever may facilitate thermal tachypnoea and/or play a role in the origin of respiratory instability accompanying febrile response.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
