Abstract
The present study was designed to determine whether whole body injection of lipopolysaccharide increases endogenous rat brain morphine levels. High performance liquid chromatography coupled to electrochemical detection and gas-chromatography mass spectrometry reveal that the resting brain morphine level is 7.0±3.2 ng/g wet weight. In a time dependent manner, intraperitoneal injection of lipopolysaccharide (10 μg), leads to an increase of brain morphine level with a peak reaching after 36 h post injection. After 72 h following the lipopolysaccharide-injection, morphine levels increased to 66.0±5.4 ng/g brain wet weight ( P<0.001). Furthermore, 96 h of fasting also increased the brain morphine level to 44.0±3.6 ng/g of brain wet weight. These results suggest that rat brain morphinergic processes respond to organismic challenges after a significant latent period.
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