Abstract
Ibuprofen was investigated with the use of reversed phase thin layer chromatography on RP2F254, RP8F254s, and RP18F254s (E. Merck), using methanol-water in different volume compositions as a mobile phase. The chromatographic parameters of lipophilicity (RMW(RP2), RMW(RP8), and RMW(RP18)) of the studied ibuprofen were determined. The experimental n-octanol-water partition coefficient (logPexp) by means of the so called shake flash method was determined for ibuprofen. Lipophilic parameters (RMW(RP2), RMW(RP8), and RMW(RP18)) were compared, both with measured (logPexp) and calculated partition coefficients (AlogPs, AClogP, AB/logP, COSMOFrag logP, miLogP, AlogP, mlogP, logPKowwin, xlogP2, xlogP3, and logPRekker). Comparing all calculation procedures, generally logPKowwin and logPRekker are more appropriate for the chromatographic parameter of lipophilicity RMW(RP18) and experimental n-octanol-water partition coefficient of the studied ibuprofen. The results indicate that the chromatographic parameter of lipophilicity determined on a RP18F254s plate may be used as a measure of lipophilicity of the investigated ibuprofen.
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