Abstract
Lipophilicity is a key physicochemical property that plays a critical role in determining ADMET properties and the overall suitability of drug candidates. Increasing evidence suggests that control of physicochemical properties like lipophilicity, within a defined optimal range, can improve compound quality and the likelihood of therapeutic success. Particular attention to this optimum region of lipophilicity as well as monitoring of lipophilic efficiency indices such as LLE and LELP may contribute significantly to the overall quality of candidate drugs throughout drug development.
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