Abstract
Various drugs bearing a thiol or thione function were coupled with activated lipophilic thiol derivatives to afford unsymmetrical disulfides. Synthetic methods were developed to introduce one or two long alkyl chains into drug molecules in order to obtain highly lipophilic prodrugs. These might be suitable to form bilayers or for integration into liposomes. Disulfide bond cleavage was assessed by preincubation of the 6-MP prodrug 2 in serum followed by a bioassay. The preincubation period did not increase the inhibitory potency of the prodrug on lymphocyte proliferation as compared to the parent drug. Thus disulfide bond cleavage of prodrug 2 is assumed to be an active cellular process.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
