Lipophilic components and evaluation of the cytotoxic and antioxidant activities of &lt;em&gt;Impatiens glandulifera&lt;/em&gt; Royle and &lt;em&gt;Impatiens noli – tangere&lt;/em&gt; L. (Balsaminaceae)

K Szewczyk,J Abramek,A Bogucka-Kocka,A Maciąg-Krajewska,R Bonikowski

doi:10.3989/gya.0234181

Lipophilic components and evaluation of the cytotoxic and antioxidant activities of <em>Impatiens glandulifera</em> Royle and <em>Impatiens noli – tangere</em> L. (Balsaminaceae)

K Szewczyk, J Abramek + Show 3 more

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https://doi.org/10.3989/gya.0234181

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Abstract

The chemical composition of the lipophilic fractions of Impatiens glandulifera Royle and I. noli-tangere L. were analyzed by gas chromatography-mass spectrometry (GC-MS)., The study focused on the fatty acids, triterpenoids and sterols in the leaves, roots and seeds. Most of the identified compounds are new for these species. a-linolenic, oleic and palmitic acids were the most abundant in the fatty acid fractions, β-amyrin and 5a-lup-20(29)-en-3β-ol in the triterpenoid fractions, and β-sitosterol, spinasterol and chondrillasterol in the sterol fractions. The fatty acid and triterpenoid fractions showed strong antioxidant activity, similar to positive controls. Moreover, the triterpenoid fraction from I. noli-tangere seeds significantly inhibited HL-60 human leukemia cells. Other fractions showed moderate cytotoxicity. The present study suggests that I. glandulifera and I. noli-tangere are good source of omega-3 fatty acids, and they might be considered as antioxidant and chemopreventive agents.

Highlights

Impatiens glandulifera Royle and Impatiens nolitangere L. are an annual herbaceous species which belongs to the Balsaminaceae family
From a chemical point of view, I. glandulifera and I. noli-tangere have been the subject of few studies which have reported on the isolation or identification of flavonoids (Szewczyk et al, 2016a), phenolic acids (Szewczyk and Olech, 2017), essential oils (Szewczyk et al, 2016b), triterpenoid saponins (Grabowska et al, 2017), glucosylated steroids (Cimmino et al, 2016), and naphthoquinones (Lobstein et al, 2001; Tříska et al, 2013)
It has been reported that several Impatiens species have valuable biological properties

Summary

Introduction

Impatiens glandulifera Royle and Impatiens nolitangere L. are an annual herbaceous species which belongs to the Balsaminaceae family. These plants are native to North-Western, Central Europe and Asia (Tříska et al, 2013). From a chemical point of view, I. glandulifera and I. noli-tangere have been the subject of few studies which have reported on the isolation or identification of flavonoids (Szewczyk et al, 2016a), phenolic acids (Szewczyk and Olech, 2017), essential oils (Szewczyk et al, 2016b), triterpenoid saponins (Grabowska et al, 2017), glucosylated steroids (Cimmino et al, 2016), and naphthoquinones (Lobstein et al, 2001; Tříska et al, 2013). The plant is utilized in Chinese medicine for rheumatism therapy; in treating fractures, swellings and contusions, as well as beriberi disease and as a plant with anticancer properties (Fukumoto et al, 1996)

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