Abstract
Synthetic lipopeptides derived from the N-terminus of bacterial lipoprotein constitute potent immunoadjuvants for parenteral and mucosal immunization. When combined with tetanus toxoid (TT) or gliadin as antigens, the lipopeptide N-palmitoyl- S-[2,3-bis(palmitoyloxy)-(2 RS)-propyl]-( R)-cysteinyl-seryl-(lysyl) 3-lysine (P 3CSK 4) markedly enhanced the specific antibody levels. Lipopeptides also act as macrophage/monocyte activators: P 3CSK 4 induced nitric oxide release from bone marrow-derived macrophages (BMDM) of LPS responder and nonresponder mice. The antitumoral effect of the lipopeptide was demonstrated by a strong cytostatic activity of the lipopeptide-treated macrophages against the murine B-cell lymphoma cell line Abelson 8-1. The chemically well-defined lipopeptides can be synthesized with high purity and reproducibility and constitute ideal agents to be combined with antigens/vaccines or antitumor treatment.
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