Abstract
Background Campylobacter cause morbidity and considerable economic loss due to hospitalization and post infectious sequelae such as reactive arthritis, Guillain Barré- and Miller Fischer syndromes. Such sequelae have been linked to C. jejuni harboring sialic acid structures in their lipooligosaccharide (LOS) layer of the cell wall. Poultry is an important source of human Campylobacter infections but little is known about the prevalence of sialylated C. jejuni isolates and the extent of transmission of such isolates to humans.ResultsGenotypes of C. jejuni isolates from enteritis patients were compared with those of broiler chicken with pulsed-field gel electrophoresis (PFGE), to study the patterns of LOS biosynthesis genes and other virulence associated genes and to what extent these occur among Campylobacter genotypes found both in humans and chickens. Chicken and human isolates generally had similar distributions of the putative virulence genes and LOS locus classes studied. However, there were significant differences regarding LOS locus class of PFGE types that were overlapping between chicken and human isolates and those that were distinct to each source.ConclusionsThe study highlights the prevalence of virulence associated genes among Campylobacter isolates from humans and chickens and suggests possible patterns of transmission between the two species.
Highlights
Campylobacter cause morbidity and considerable economic loss due to hospitalization and post infectious sequelae such as reactive arthritis, Guillain Barré- and Miller Fischer syndromes
Pulsed field gel electrophoresis (PFGE) showed that the 163 C. jejuni isolates fell into 66 different Restriction enzyme from Serratia marcescens (SmaI) types
In conclusion, we found that the prevalences of the different LOS locus classes in general, and of the putative virulence factors fucose permease (fucP), Gene encoding an iron transport protein (ceuE), phospholipase gene (pldA) and Campylobacter invasion antigen (ciaB) were similar among human and chicken C. jejuni isolates in Sweden
Summary
Campylobacter cause morbidity and considerable economic loss due to hospitalization and post infectious sequelae such as reactive arthritis, Guillain Barré- and Miller Fischer syndromes. Such sequelae have been linked to C. jejuni harboring sialic acid structures in their lipooligosaccharide (LOS) layer of the cell wall. Campylobacter is the most common cause of bacterial enteritis in the western world accounting for more than 200 000 reported human infections per year in the EU [1]. In some cases patients need to be hospitalized due to severe enteritis or to sequelae such as reactive arthritis, Guillain Barré- or Miller Fischer syndromes [2,3,4,5]. Campylobacter is a zoonotic pathogen and the Ellström et al BMC Microbiology (2016) 16:116
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