Abstract
Lipomatous neurofibroma is a special subtype of neurofibroma, which includes abundant mature adipoid tissue, and usually presents subcutaneous location. We describe herein an exceptionally rare case of lipomatous neurofibroma of the tongue. The patient was a 46-year-old Japanese female, who had a well demarcated mass lesion of the tongue. The tumor was composed of mature adipoid tissue and haphazardly arranged spindle cells, which lacked cellular atypia and mitotic activity. Also lipoblast-mimicking cells with intracytoplasmic vacuoles were intermingled within the tumor. Immunohistochemical study revealed strong positive reaction for S100 protein in the tumor. While spindle cells were negative for CD34, alpha-smooth muscle actin, neurofilament, Leu-7, glial fibrillary acidic protein, p63, epithelial membrane antigen and cytokeratin AE1/AE3, type IV collagen highlighted delicate fibrillary cytoplasmic process. Although tumor cells were negative for SOX10 as well, positive cells were sporadically identified within the fibrous capsule, which could suggest intraneural occurrence of the tumor.
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